SYNTHETIC SUBSTITUTES FOR QUINIDINE

The Efficacy of Synthetic Bone Graft Substitutes

One of the most difficult challenges in orthopaedics is the treatment of large bone voids or defects. While autografts have traditionally been considered a standard treatment, this procedure has been associated with complications such as increased incidence of pain, nerve injury, arterial damage, harvest site fracture, hematoma, infection, and compromised patient function. Synthetic bone graft ...

Staining undecalcified bone sections a modified technique for an improved visualization of synthetic bone substitutes.

We describe a detailed embedding procedure for large bone specimens in methyl methacrylate and a new staining method by which thin sections (appr 100 um) of undecalcified bones with synthetic implants can be coloured. Different staining effects were obtained which greatly facilitated the evaluation of sections with bone, new forming bone and especially remnants of synthetic implants. The identi...

Doped Calcium Silicate Ceramics: A New Class of Candidates for Synthetic Bone Substitutes

Doped calcium silicate ceramics (DCSCs) have recently gained immense interest as a new class of candidates for the treatment of bone defects. Although calcium phosphates and bioactive glasses have remained the mainstream of ceramic bone substitutes, their clinical use is limited by suboptimal mechanical properties. DCSCs are a class of calcium silicate ceramics which are developed through the i...

Research on Fat Substitutes

Fodd Scientists and technologists have long been searching for fat su bstitutes, i.e. compounds with physical and organoleptic properties similar to conventional dietary fats and oils but with as few calories as possible. After many years of persistant efforts, they have recently achieved considerable sussess in this field. Since a diet high in fat and cholesterol is regarded as an important fa...

The search for blood substitutes.